APS Phenadrine 60c





APS Phenadrine 60c
Retail Price: $59.95
Your Price: $32.99





APS Phenadrine 60 Caps

Product Description

Advanced Lipolytic Stimulant!

Based on a carefully crafted unique matrix of proven and effective agents, coupled with advanced and highly innovative compounds at potent pharmaceutical-grade doses, Phenadrine effortlessly takes versatility and synergy to completely new levels. With a two-in-one punch, Phenadrine fuses advanced lipolytic stimulation and intense workout potentiation like no other supplement. A standard setter, Phenadrine will deliver results right from the first dose. Every time! No tolerance build up! No hit-and-miss! Phenadrine was engineered to work; to catapult your performance to a new league. Get ready for the most intense workout and fat-melting experience of your life!

Phenadrine delivers:

  • Unparalleled pre-workout and fat-incinerating results
  • The most intense workout of your life. Every time!
  • Intense focus, concentration, mental clarity and alertness
  • Previously unknown levels of jitter-free energy with no crashes
  • Dramatic boost in energy and physical performance
  • Advanced multiple pathways for rapid and effective fat-loss
  • Increased vascularity and pump
  • Enhanced protein synthesis and elevated testosterone production
  • Modulation of estrogen and cortisol levels
  • Improved sexual performance

    Engineered to unleash previously unknown levels of synergy, Phenadrine's unsurpassed actives, including the novel and single most effective designer fat-loss compound, N-Methyl-Beta-Methylphenylethylamine HCL, collectively yield a new standard-setting advanced pharmaceutical-grade lipolytic stimulant and intense workout initiator.

    The matrix consists of:

    N-Acetyl L-Tyrosine:

    N-Acetyl-Tyrosine (NAT) is an acetylated form of the essential amino acid, L-Tyrosine. NAT is more water soluble, and is therefore, a rapidly absorbed and more bio-available form than pure L-Tyrosine. L-Tyrosine modulates the synthesis of cortisol and thyroid hormones, as well as that of neurotransmitter catecholamines such norepinephrine (noradrenaline), epinephrine (adrenaline) and dopamine, that are depleted by stress. So, NAT supplementation reduces the impact of stress and fatigue and elevates cognitive performance. The neurotransmitter-stimulation action of NAT further synchronizes with similar synergistic action from 1,3-Dimetylamylamine and caffeine (caffeine stimulates release of catecholamines and NAT modulates their synthesis), leading to enhanced thermogenesis and lipolysis. Furthermore, by modulating thyroid hormones, NAT supports optimised base metabolic rate, promotes protein synthesis and glucose metabolism, enhances lipid metabolism by increasing adipose tissue sensitivity to hormones that modulate fat breakdown. As is well known, even a slight increase in active thyroid-hormone levels can produce a dramatic improvement in metabolism, energy levels, and mental attitude. Besides, NAT's cortisol-modulating impact supports reduced fatigue, better recovery, and reduced adipose storage.

    Icariin:

    An epimedium flavonoid and testosterone mimetic, icariin is a natural anabolic that possesses a variety of unique pharmacological actions in the body. It plays an important role in modulating nitric oxide levels by inhibiting an important enzyme, phosphodiesterase type 5 (PDE-5), that breaks down another enzyme, 3',5'-cyclic Guanosine Monophosphate (cGMP). cGMP signals the smooth muscles to relax, enhancing blood flow. So, PDE-5 inhibition prolongs the action of cGMP, making possible the flooding of skeletal muscle tissue with nutrient-rich blood and oxygen, leading to improved muscle contraction, intense pump and vascularity, as well as promoting an environment conducive to anabolism. This PDE-5 inhibition is also the mechanism behind icariin's dramatic improvement in sexual function in users. Furthermore, icariin, like testosterone, competes with glucocorticoids for receptor-site binding. By blocking glucocorticoids from binding to cortisol receptor sites, icariin inhibits cortisol action. This leads to an increase in the testosterone:cortisol ratio, triggering enhanced protein synthesis and anabolism. Furthermore, icariin produces a boost in cAMP levels, demonstrates estrogen-modulation properties, stimulates prolactin inhibition (via its action on dopamine receptors, thereby triggering an increased testosterone production), and promotes increased production of luteinizing hormone. Net, the cAMP elevation, selective cGMP inhibition, glucocorticoid antagonism, and estrogen modulation, all combine to improve the testosterone:cortisol and testosterone:estrogen ratios. Furthermore, via its function as an important acetylcholinesterase inhibitor, icariin boosts levels of the neurotransmitter, acetylcholine. This inhibition drives movement and promotes stronger muscle contractions, and a dense skeletal muscle structure.

    Caffeine:

    Caffeine, a methylxanthine and popular stimulant, not only possesses lipolytic and appetite suppressant properties, but also helps to enhance endurance and extent the effect of other stimulants. As a CNS stimulant, caffeine works as an adenosine A1 and A2A receptor antagonist. This is significant because adenosine modulates the action of neurotransmitters such as dopamine, norepinephrine, and acetylcholine. Adenosine blocks the activity of excitatory neurotransmitters, creating a tatigue and a feeling of apathy. By antagonizing adenosine, caffeine stimulates nerve-cell activity, creating enhanced alertness and clarity. Furthermore, caffeine inhibits the enzyme, phosphodiesterase (PDE), that breaks down cAMP. This PDE inhibition leads to sustained cAMP activity and boosting norepinephrine, thereby up-regulating thermogenesis and lipolysis. These pathways ensure caffeine traces a synergistic action with 1,3-Dimethylamylamine and other agents in Phenedrine, creating an optimally fuelled fat-burning furnace in your body.

    Something else:

    Two enzymes, arginase and nitric oxide synthase compete against each other for the nitric-oxide metabolic pathway. The enzyme arginase converts arginine to ornithine and urea. Nitric oxide synthase converts arginine to nitric oxide, the potent vasodilator. A higher expression of the arginase enzyme leads to higher ornithine production, but less nitric oxide production. Now enters caffeine (methylxanthine caffeine). Caffeine inhibits arginase activity. It does this by inhibiting the so-called adenosine receptors, leading to higher levels of free adenosine. Now, adenosine, adenine, inosine, and uric acid, are known to be competitive arginase inhibitors. Furthermore, caffeine and caffeine-related compounds, also produce arginase inhibition by raising norepinephrine and cAMP. The caffeine-triggered arginase inhibition produces an elevated expression of the nitric-oxide synthase enzyme. This means even more nitric oxide is made available, leading to stronger vasodilation (and pump).

    1,3-Dimethylamylamine:

    Also known as Geranamine, 1,3-Dimethylamylamine, a derivative of geranium oil, possesses a pharmacological activity similar to that of epinephrine (adrenaline), the body's endogenous chemical messenger. As a potent fat burner, 1,3-Dimethylamylamine activates an enzyme, adenylate cyclase, that elevates cyclic adenosine monophosphate (cAMP) in cells, triggering fat metabolism. This is also one of the chemical pathways employed by ephedrine to potentiate fat burning. Furthermore, 1,3-Dimethylamylamine demonstrates potent central-nervous system (CNS) stimulation, leading to enhanced energy and physical performance, heightened focus and concentration, enabling the user to achieve a previously unknown intensity during training. The user will experience a significant elevation in energy levels without the usual crash common with many other stimulants. 1,3-Dimethylamylamine is often combined with caffeine to further consolidate the heightened energy, intense concentration and focus, as well as euphoric feelings.

    N-Methyl-Beta-Methylphenylethylamine HCL:

    This is a truly unique and novel compound, and one of compounds that sets Phenadrine apart from competition. Chances are you are familiar with the pharmacological pathways of Beta-Phenylethylamine (PEA). You may also be familiar with N-Methyl-Beta-Phenylethylamine HCL. Yet, do not confuse N-Methyl-Beta-Phenylethylamine HCL with our much more potent agent, N-Methyl-Beta-Methylphenylethylamine HCL with several methyl groups that render it super stable and remorselessly effective. This novel agent works! That simple! References:Armstrong WJ, Johnson P, Duhme S. The effect of commercial thermogenic weight loss supplement in body composition and energy expenditure in obese adults. J Exerc Physiol. 2001 4: 28-35, 2001.

    Banderet, LE, and Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762, 1989.

    Bell, DG, McLellan, TM. Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. J Appl Physiol. 2002 Oct;93(4):.

    Bent S, Padula A, Neuhaus J. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol. 2004 Nov 15;94(10):.

    Bui LT, Nguyen DT, Ambrose PJ. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother. 2006 Jan;40(1):53-7. Epub 2005 Nov 29.

    Camp BJ. Action of N-methyltyramine and N-methyl beta-phenylethylamine on certain biological systems. Am J Vet Res. 1970, 31(4): 755-762.

    Carpéné C, Galitzky J, Fontana E, Atgié C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):310-21.

    Cooper SJ, Dourish CT. Hypodipsia, stereotypy and hyperactivity induced by beta-phenylethylamine in the water-deprived rat. Pharmacol Biochem Behav. 1984, 20(1): 1-7.

    Colker CM, Kalman DS, Torina GC, Perlis T, Street C. Effects of Citrus aurantium extract, caffeine, and St. John's Wort on body fat loss, lipid levels, and mood states in overweight, healthy adults. Curr Ther Res. 1999; 60:145-153.

    Cox GR, Desbrow B, Montgomery PG, Anderson ME, Bruce CR, Macrides TA, Martin DT, Moquin A, Roberts A, Hawley JA, Burke LM. Effect of different protocols of caffeine intake on metabolism and endurance performance. J Appl Physiol. 2002 Sep;93(3):990-9.

    Davis JM, Zhao Z, Stock HS, Mehl KA, Buggy J, Hand GA. Central nervous system effects of caffeine and adenosine on fatigue. Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R399-404. Epub 2002 Oct 24.

    Dollins AB, Krock LP, Storm WF, Wurtman RJ, Lieberman HR. L-tyrosine ameliorates some effects of lower body negative pressure stress. Physiol Behav. 1995 Feb;57(2):223-30.

    Dourish CT, Greenshaw AJ, Boulton AA. Deutrium substitution enhances the effects of b-phenylethylamine on spontaneous motor activity in the rat. Pharmacol. Biochem. Behav. 1983, 19: 471-475.

    Dourish CT, Boulton AA. The effects of acute and chronic administration of beta-phenylethylamine on food intake and body weight in rats. Prog Neuropsychopharmacol. 1981, 5(4): 411-414.

    Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev. 2006 Feb;7(1):79-88.

    Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997, 17(2): 206-210.

    Hull EM, Muschamp JW, Sato S. Dopamine and serotonin: influences on male sexual behavior. Physiol Behav. 2004 Nitric oxidev 15;83(2):291-307Jessen A, Buemann B, Toubro S, Skovgaard IM, Astrup A. The appetite-suppressant effect of nicotine is enhanced by caffeine. Diabetes Obes Metab. 2005 Jul;7(4):327-33.

    Jiang, Z. et al Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats. Biol Pharm Bull. 2006 Dec;29(12):

    Jiang Z, Hu B, Wang J, Tang Q, Tan Y, Xiang J, Liu J. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum.J Huazhong Univ Sci Technolog Med Sci.2006;26(4):460-2.

    Kruger TH, Haake P, Hartmann U, Schedlowski M, Exton MS. Orgasm-induced prolactin secretion: feedback control of sexual drive? Neurosci Biobehav Rev. 2002 Jan;26(1):31-44.

    Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A. Effect of a 28-d treatment with L-, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002 Oct;76(4):780-8.

    Lee MK, Choi YJ, Sung SH, Shin DI, Kim JW, Kim YC. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med. 1995 Dec;61(6):523-6.

    Liang HR, Vuorela P, Vuorela H, Hiltunen R. Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Planta Med. 1997 Aug;63(4):316-9.

    Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL. Effects of icariin and expression of nitric oxide synthase isoforms in rats. Asian J Androl. 2005 Dec;7(4):381-8.

    Liu ZQ. Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles. J Phys Chem A Mol Spectrosc Kinet Environ Gen Theory. 2006 May 18;110(19):6372-8.

    Nakamura M, Ishii A, Nakahara D. Characterization of b-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur. J. Pharmacol. 1998, 349: 163-169.

    Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995 Apr;66(4):313-9.

    Ning, H et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4.

    Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4.

    O'Reilly R, Davis BA, Durden DA, Thorpe L, Machnee H, Boulton AA. Plasma phenylethylamine in schizophrenic patients. Biol Psychiatry. 1991, 30(2): 145-150.

    Pan Y, Kong L, Xia X, Zhang W, Xia Z, Jiang F. Effect of icariin and its possible mechanism in mice. Pharmacol Biochem Behav. 2005 Dec;82(4):686-94.

    Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jun 2;84(11):954-7. Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernitric oxidesum of arterigenic erectile dysfunction rat model

    Xu HB, Huang ZQ. Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascular Pharmacology. 2007 Jul;47(1):18-24. Epub 2007 Mar 24.

    Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian Journal of Andrology. 2003 Mar;5(1):15-8.

    Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Asian J Androl. 2003 Mar;5(1):15-8. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.

    Xu HB, Huang ZQ. Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul Pharmacol. 2007 Jul;47(1):18-24.Young ME, Leighton B.(1998) Evidence for altered sensitivity of the nitric oxide/cGMP signaling cascade in insulin-resistant skeletal muscle. Biochem J. Jan 1;329 ( Pt 1):73-9

    Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian J Androl. 2006 Sep;8(5):601-5.


    Supplement Facts:

    Serving Size: 1 capsule
    Servings Per Container: 60

    Amount Per Serving:

    Phenylean Proprietary Matrix: 750mg*
    N-Acetyl Tyrosine, Icariin (50%), Caffeine Anhydrous, 1,3 Dimethylamylamine, N-Methyl-Beta-Methylphenylethylamine HCL, Methylsynephrine

    * Daily Value not established

    Other Ingredients:Gelatin, Magnesium Stearate, Titanium Dioxide, Silica, FD&C #40.

    Directions: Take one capsule 30 min before workout. After assessing tolerance experienced users may increase to two capsules 30 min before workout.

    PHENADRINE is also an amazing fat burner!

    If taking for fat loss only, take one capsule in the morning or early afternoon. Do not exceed two capsules of Phenadrine a day under any circumstances. Take at least 2 days off Phenadrine every week.

    Warnings: Keep Out Of Reach Of Children. Not for use by individuals under the age of 20. Do not use if you are pregnant or nursing. Do not use if you have or have a family history of any of the following: high blood pressure, asthma, diabetes, liver, kidney or thyroid disease, any kind of heart problem including but not limited to arrhythmia and angina persistent headaches, any variation of nervousness, anxiety, depression or any other psychiatric condition, seizures, stroke or problem with vascular system, or Parkinson's disease. Do not use if you are using an MAOI or any other supplement or drug containing stimulants including but not limited to coffee. Exceeding recommended dose may cause adverse health effects. Discontinue use and contact your physician immediately if you experience rapid heartbeat, dizziness, shortness of breath, severe headache or any other sensation that may be unusual or abnormal. Do not use this supplement in excessive heat (temperature) conditions.

    These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

    PLEASE NOTE: Product image is representative of the product offered but may not have the exact attributes. Please read product description for the specific attributes of thisproduct.

     

    PLEASE NOTE: The information above is intended for reference only. While we attempt to keep our information accurate, we cannot guarantee it is an accurate representation of the latest formulation of the product. If you have any concerns, please visit the vendor's web site. The information above are the views of the product's manufacturer, not the views of Muscle 4 Life Nutrition LLC. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    Prices are subject to change at any time and some items are limited to stock on hand.




  • How M4LN Handles & Processes Your Order

    1.Payments are processed securely through PayPal which accept many forms of online payments - paypal, credit cards, or other types of payments

    2. Immediately after placing your order, you will receive an email confirmation containing your receipt, transaction ID number & other important information.

    3. When an order is placed during regular business hours, we typically ship it that very same day. When you order later in the day, your shipment is prepared and packaged the very next morning. When an order is placed over the weekend the order will ship first thing Monday morning.

    4. After your order is shipped, you will receive an email with your tracking number.

    5. Before you know it a delivery person will knock on your door and deliver your order!

    6.NOTE: If your shipping address is in Hawaii, Alaska, a PO Box, or an APO/FPO address, please email us for specific shipping prices






    Return To Energy & Endurance Products Page

    Return To Pre-Workout Products Page

    New! Comments

    Have your say about what you just read! Leave me a comment in the box below.



    Enter your E-mail Address
    Enter your First Name (optional)
    Then

    Don't worry — your e-mail address is totally secure.
    I promise to use it only to send you Performance Supplements That Work!.